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Ehrlichia type IV secretion system effector Etf-2 binds to active RAB5 and delays endosome maturation
Ehrlichia chaffeensis, an obligatory intracellular bacterium, infects monocytes/macrophages by sequestering a regulator of endosomal traffic, the small GTPase RAB5, on its membrane-bound inclusions to avoid routing to host-cell phagolysosomes. How RAB5 is sequestered on ehrlichial inclusions is poor...
Autores principales: | Yan, Qi, Lin, Mingqun, Huang, Weiyan, Teymournejad, Omid, Johnson, Jennifer M., Hays, Franklin A., Liang, Zhimin, Li, Guangpu, Rikihisa, Yasuko |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156607/ https://www.ncbi.nlm.nih.gov/pubmed/30181274 http://dx.doi.org/10.1073/pnas.1806904115 |
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