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Nucleosomes inhibit target cleavage by CRISPR-Cas9 in vivo
Genome editing with CRISPR-Cas nucleases has been applied successfully to a wide range of cells and organisms. There is, however, considerable variation in the efficiency of cleavage and outcomes at different genomic targets, even within the same cell type. Some of this variability is likely due to...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156633/ https://www.ncbi.nlm.nih.gov/pubmed/30201707 http://dx.doi.org/10.1073/pnas.1810062115 |