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14-3-3εa directs the pulsatile transport of basal factors toward the apical domain for lumen growth in tubulogenesis
The Ciona notochord has emerged as a simple and tractable in vivo model for tubulogenesis. Here, using a chemical genetics approach, we identified UTKO1 as a selective small molecule inhibitor of notochord tubulogenesis. We identified 14-3-3εa protein as a direct binding partner of UTKO1 and showed...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156656/ https://www.ncbi.nlm.nih.gov/pubmed/30158171 http://dx.doi.org/10.1073/pnas.1808756115 |