Cargando…

14-3-3εa directs the pulsatile transport of basal factors toward the apical domain for lumen growth in tubulogenesis

The Ciona notochord has emerged as a simple and tractable in vivo model for tubulogenesis. Here, using a chemical genetics approach, we identified UTKO1 as a selective small molecule inhibitor of notochord tubulogenesis. We identified 14-3-3εa protein as a direct binding partner of UTKO1 and showed...

Descripción completa

Detalles Bibliográficos
Autores principales: Mizotani, Yuji, Suzuki, Mayu, Hotta, Kohji, Watanabe, Hidenori, Shiba, Kogiku, Inaba, Kazuo, Tashiro, Etsu, Oka, Kotaro, Imoto, Masaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156656/
https://www.ncbi.nlm.nih.gov/pubmed/30158171
http://dx.doi.org/10.1073/pnas.1808756115

Ejemplares similares