Autoreactive IgG and IgA B Cells Evolve through Distinct Subclass Switch Pathways in the Autoimmune Disease Pemphigus Vulgaris

Lineage analysis of autoreactive B cells can reveal the origins of autoimmunity. In the autoimmune disease pemphigus vulgaris (PV), desmoglein 3 (DSG3) and DSG1 autoantibodies are predominantly of the IgG4 subclass and less frequently of IgG1 and IgA subclasses, prompting us to investigate whether a...

Descripción completa

Detalles Bibliográficos
Autores principales: Ellebrecht, Christoph T., Mukherjee, Eric M., Zheng, Qi, Choi, Eun Jung, Reddy, Shantan G., Mao, Xuming, Payne, Aimee S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156788/
https://www.ncbi.nlm.nih.gov/pubmed/30157430
http://dx.doi.org/10.1016/j.celrep.2018.07.093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156788/
https://www.ncbi.nlm.nih.gov/pubmed/30157430
http://dx.doi.org/10.1016/j.celrep.2018.07.093

Ejemplares similares