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CRISPR/Cas9-mediated genome editing induces exon skipping by complete or stochastic altering splicing in the migratory locust

BACKGROUND: The CRISPR/Cas9 system has been widely used to generate gene knockout/knockin models by inducing frameshift mutants in cell lines and organisms. Several recent studies have reported that such mutants can lead to in-frame exon skipping in cell lines. However, there was little research abo...

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Detalles Bibliográficos
Autores principales:	Chen, Dafeng, Tang, Ji-Xin, Li, Beibei, Hou, Li, Wang, Xianhui, Kang, Le
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Methodology Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156852/ https://www.ncbi.nlm.nih.gov/pubmed/30253761 http://dx.doi.org/10.1186/s12896-018-0465-7

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