Synaptic coupling of inner ear sensory cells is controlled by brevican-based extracellular matrix baskets resembling perineuronal nets
BACKGROUND: Perineuronal nets (PNNs) are specialized aggregations of extracellular matrix (ECM) molecules surrounding specific neurons in the central nervous system (CNS). PNNs are supposed to control synaptic transmission and are frequently associated with neurons firing at high rates, including pr...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156866/ https://www.ncbi.nlm.nih.gov/pubmed/30253762 http://dx.doi.org/10.1186/s12915-018-0566-8 |
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author | Sonntag, Mandy Blosa, Maren Schmidt, Sophie Reimann, Katja Blum, Kerstin Eckrich, Tobias Seeger, Gudrun Hecker, Dietmar Schick, Bernhard Arendt, Thomas Engel, Jutta Morawski, Markus |
author_facet | Sonntag, Mandy Blosa, Maren Schmidt, Sophie Reimann, Katja Blum, Kerstin Eckrich, Tobias Seeger, Gudrun Hecker, Dietmar Schick, Bernhard Arendt, Thomas Engel, Jutta Morawski, Markus |
author_sort | Sonntag, Mandy |
collection | PubMed |
description | BACKGROUND: Perineuronal nets (PNNs) are specialized aggregations of extracellular matrix (ECM) molecules surrounding specific neurons in the central nervous system (CNS). PNNs are supposed to control synaptic transmission and are frequently associated with neurons firing at high rates, including principal neurons of auditory brainstem nuclei. The origin of high-frequency activity of auditory brainstem neurons is the indefatigable sound-driven transmitter release of inner hair cells (IHCs) in the cochlea. RESULTS: Here, we show that synaptic poles of IHCs are ensheathed by basket-like ECM complexes formed by the same molecules that constitute PNNs of neurons in the CNS, including brevican, aggreccan, neurocan, hyaluronan, and proteoglycan link proteins 1 and 4 and tenascin-R. Genetic deletion of brevican, one of the main components, resulted in a massive degradation of ECM baskets at IHCs, a significant impairment in spatial coupling of pre- and postsynaptic elements and mild impairment of hearing. CONCLUSIONS: These ECM baskets potentially contribute to control of synaptic transmission at IHCs and might be functionally related to PNNs of neurons in the CNS. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12915-018-0566-8) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6156866 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-61568662018-09-27 Synaptic coupling of inner ear sensory cells is controlled by brevican-based extracellular matrix baskets resembling perineuronal nets Sonntag, Mandy Blosa, Maren Schmidt, Sophie Reimann, Katja Blum, Kerstin Eckrich, Tobias Seeger, Gudrun Hecker, Dietmar Schick, Bernhard Arendt, Thomas Engel, Jutta Morawski, Markus BMC Biol Research Article BACKGROUND: Perineuronal nets (PNNs) are specialized aggregations of extracellular matrix (ECM) molecules surrounding specific neurons in the central nervous system (CNS). PNNs are supposed to control synaptic transmission and are frequently associated with neurons firing at high rates, including principal neurons of auditory brainstem nuclei. The origin of high-frequency activity of auditory brainstem neurons is the indefatigable sound-driven transmitter release of inner hair cells (IHCs) in the cochlea. RESULTS: Here, we show that synaptic poles of IHCs are ensheathed by basket-like ECM complexes formed by the same molecules that constitute PNNs of neurons in the CNS, including brevican, aggreccan, neurocan, hyaluronan, and proteoglycan link proteins 1 and 4 and tenascin-R. Genetic deletion of brevican, one of the main components, resulted in a massive degradation of ECM baskets at IHCs, a significant impairment in spatial coupling of pre- and postsynaptic elements and mild impairment of hearing. CONCLUSIONS: These ECM baskets potentially contribute to control of synaptic transmission at IHCs and might be functionally related to PNNs of neurons in the CNS. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12915-018-0566-8) contains supplementary material, which is available to authorized users. BioMed Central 2018-09-26 /pmc/articles/PMC6156866/ /pubmed/30253762 http://dx.doi.org/10.1186/s12915-018-0566-8 Text en © Morawski et al. 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Sonntag, Mandy Blosa, Maren Schmidt, Sophie Reimann, Katja Blum, Kerstin Eckrich, Tobias Seeger, Gudrun Hecker, Dietmar Schick, Bernhard Arendt, Thomas Engel, Jutta Morawski, Markus Synaptic coupling of inner ear sensory cells is controlled by brevican-based extracellular matrix baskets resembling perineuronal nets |
title | Synaptic coupling of inner ear sensory cells is controlled by brevican-based extracellular matrix baskets resembling perineuronal nets |
title_full | Synaptic coupling of inner ear sensory cells is controlled by brevican-based extracellular matrix baskets resembling perineuronal nets |
title_fullStr | Synaptic coupling of inner ear sensory cells is controlled by brevican-based extracellular matrix baskets resembling perineuronal nets |
title_full_unstemmed | Synaptic coupling of inner ear sensory cells is controlled by brevican-based extracellular matrix baskets resembling perineuronal nets |
title_short | Synaptic coupling of inner ear sensory cells is controlled by brevican-based extracellular matrix baskets resembling perineuronal nets |
title_sort | synaptic coupling of inner ear sensory cells is controlled by brevican-based extracellular matrix baskets resembling perineuronal nets |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156866/ https://www.ncbi.nlm.nih.gov/pubmed/30253762 http://dx.doi.org/10.1186/s12915-018-0566-8 |
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