An adaptive gene-level association test for pedigree data

BACKGROUND: We propose a gene-level association test that accounts for individual relatedness and population structures in pedigree data in the framework of linear mixed models (LMMs). Our method data-adaptively combines the results across a class of score-based tests, only requiring fitting a singl...

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Detalles Bibliográficos
Autores principales: Park, Jun Young, Wu, Chong, Pan, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157189/
https://www.ncbi.nlm.nih.gov/pubmed/30255770
http://dx.doi.org/10.1186/s12863-018-0639-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157189/
https://www.ncbi.nlm.nih.gov/pubmed/30255770
http://dx.doi.org/10.1186/s12863-018-0639-2

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