Loss of Tbk1 kinase activity protects mice from diet-induced metabolic dysfunction

OBJECTIVE: TANK Binding Kinase 1 (TBK1) has been implicated in the regulation of metabolism through studies with the drug amlexanox, an inhibitor of the IκB kinase (IKK)-related kinases. Amlexanox induced weight loss, reduced fatty liver and insulin resistance in high fat diet (HFD) fed mice and has...

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Detalles Bibliográficos
Autores principales: Cruz, Victoria H., Arner, Emily N., Wynne, Katherine W., Scherer, Philipp E., Brekken, Rolf A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157474/
https://www.ncbi.nlm.nih.gov/pubmed/29935921
http://dx.doi.org/10.1016/j.molmet.2018.06.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157474/
https://www.ncbi.nlm.nih.gov/pubmed/29935921
http://dx.doi.org/10.1016/j.molmet.2018.06.007

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