Glucosamine-paracetamol spray-dried solid dispersions with maximized intrinsic dissolution rate, bioavailability and decreased levels of in vivo toxic metabolites

PURPOSE: This study is aimed at preparing and testing physicochemical, pharmacokinetic and levels of toxic metabolites of paracetamol and glucosamine solid dispersions intended for multiple deliveries via the parenteral or per oral route. METHODS: Solid dispersions were prepared using the spray dryi...

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Detalles Bibliográficos
Autores principales: Ali, Ahmed Mahmoud Abdelhaleem, Khames, Ahmed, Alrobaian, Majed Mansour, Hamaidi, Mohammad, Abourehab, Mohammed AS
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157577/
https://www.ncbi.nlm.nih.gov/pubmed/30275684
http://dx.doi.org/10.2147/DDDT.S176099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157577/
https://www.ncbi.nlm.nih.gov/pubmed/30275684
http://dx.doi.org/10.2147/DDDT.S176099

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