Oxygen producing microscale spheres affect cell survival in conditions of oxygen-glucose deprivation in a cell specific manner: implications for cell transplantation

This study outlines the synthesis of microscale oxygen producing spheres, which, when used in conjunction with catalase, can raise the dissolved oxygen content of cell culture media for 16–20 hours. In conditions of oxygen and glucose deprivation, designed to mimic the graft environment in vivo, the...

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Detalles Bibliográficos
Autores principales: Newland, Heike, Eigel, Dimitri, Rosser, Anne E., Werner, Carsten, Newland, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157640/
https://www.ncbi.nlm.nih.gov/pubmed/30132477
http://dx.doi.org/10.1039/c8bm00490k
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author Newland, Heike
Eigel, Dimitri
Rosser, Anne E.
Werner, Carsten
Newland, Ben
author_facet Newland, Heike
Eigel, Dimitri
Rosser, Anne E.
Werner, Carsten
Newland, Ben
author_sort Newland, Heike
collection PubMed
description This study outlines the synthesis of microscale oxygen producing spheres, which, when used in conjunction with catalase, can raise the dissolved oxygen content of cell culture media for 16–20 hours. In conditions of oxygen and glucose deprivation, designed to mimic the graft environment in vivo, the spheres rescue SH-SY5Y cells and meschymal stem cells, showing that oxygen producing biomaterials may hold potential to improve the survival of cells post-transplantation.
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spelling pubmed-61576402018-10-05 Oxygen producing microscale spheres affect cell survival in conditions of oxygen-glucose deprivation in a cell specific manner: implications for cell transplantation Newland, Heike Eigel, Dimitri Rosser, Anne E. Werner, Carsten Newland, Ben Biomater Sci Chemistry This study outlines the synthesis of microscale oxygen producing spheres, which, when used in conjunction with catalase, can raise the dissolved oxygen content of cell culture media for 16–20 hours. In conditions of oxygen and glucose deprivation, designed to mimic the graft environment in vivo, the spheres rescue SH-SY5Y cells and meschymal stem cells, showing that oxygen producing biomaterials may hold potential to improve the survival of cells post-transplantation. Royal Society of Chemistry 2018-10-01 2018-08-22 /pmc/articles/PMC6157640/ /pubmed/30132477 http://dx.doi.org/10.1039/c8bm00490k Text en This journal is © The Royal Society of Chemistry 2018 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
Newland, Heike
Eigel, Dimitri
Rosser, Anne E.
Werner, Carsten
Newland, Ben
Oxygen producing microscale spheres affect cell survival in conditions of oxygen-glucose deprivation in a cell specific manner: implications for cell transplantation
title Oxygen producing microscale spheres affect cell survival in conditions of oxygen-glucose deprivation in a cell specific manner: implications for cell transplantation
title_full Oxygen producing microscale spheres affect cell survival in conditions of oxygen-glucose deprivation in a cell specific manner: implications for cell transplantation
title_fullStr Oxygen producing microscale spheres affect cell survival in conditions of oxygen-glucose deprivation in a cell specific manner: implications for cell transplantation
title_full_unstemmed Oxygen producing microscale spheres affect cell survival in conditions of oxygen-glucose deprivation in a cell specific manner: implications for cell transplantation
title_short Oxygen producing microscale spheres affect cell survival in conditions of oxygen-glucose deprivation in a cell specific manner: implications for cell transplantation
title_sort oxygen producing microscale spheres affect cell survival in conditions of oxygen-glucose deprivation in a cell specific manner: implications for cell transplantation
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157640/
https://www.ncbi.nlm.nih.gov/pubmed/30132477
http://dx.doi.org/10.1039/c8bm00490k
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