Automated Scale Reduction of Nonlinear QSP Models With an Illustrative Application to a Bone Biology System

Integrating quantitative systems pharmacology (QSP) into pharmacokinetics/pharmacodynamics (PKPD) has resulted in models that are highly complex and often not amenable to further exploration via estimation or design. Because QSP models are usually depicted using nonlinear differential equations it i...

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Detalles Bibliográficos
Autores principales: Hasegawa, Chihiro, Duffull, Stephen B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157701/
https://www.ncbi.nlm.nih.gov/pubmed/30043496
http://dx.doi.org/10.1002/psp4.12324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157701/
https://www.ncbi.nlm.nih.gov/pubmed/30043496
http://dx.doi.org/10.1002/psp4.12324

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