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Automated Scale Reduction of Nonlinear QSP Models With an Illustrative Application to a Bone Biology System
Integrating quantitative systems pharmacology (QSP) into pharmacokinetics/pharmacodynamics (PKPD) has resulted in models that are highly complex and often not amenable to further exploration via estimation or design. Because QSP models are usually depicted using nonlinear differential equations it i...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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John Wiley and Sons Inc.
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157701/ https://www.ncbi.nlm.nih.gov/pubmed/30043496 http://dx.doi.org/10.1002/psp4.12324 |