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Age-specific changes in genome-wide methylation enrich for Foxa2 and estrogen receptor alpha binding sites

The role of DNA methylation patterns in complex phenotypes remains unclear. To explore this question, we adapted our methods for rare variant analysis to characterize genome-wide murine DNA hybridization array to investigate methylation at CpG islands, shores, and regulatory elements. We have applie...

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Detalles Bibliográficos
Autores principales: Uli, Nishanth, Michelen-Gomez, Eduardo, Ramos, Enrique I., Druley, Todd E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157835/
https://www.ncbi.nlm.nih.gov/pubmed/30256791
http://dx.doi.org/10.1371/journal.pone.0203147