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Tracing a protein’s folding pathway over evolutionary time using ancestral sequence reconstruction and hydrogen exchange
The conformations populated during protein folding have been studied for decades; yet, their evolutionary importance remains largely unexplored. Ancestral sequence reconstruction allows access to proteins across evolutionary time, and new methods such as pulsed-labeling hydrogen exchange coupled wit...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158009/ https://www.ncbi.nlm.nih.gov/pubmed/30204082 http://dx.doi.org/10.7554/eLife.38369 |