A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes

Attachment of ubiquitin to lysine 119 of Histone 2A (H2AK119Ub) is an epigenetic mark characteristic of repressed developmental genes, which is removed by the Polycomb Repressive-Deubiquitinase (PR-DUB) complex. Here we report the crystal structure of the Drosophila PR-DUB, revealing that the deubiq...

Descripción completa

Detalles Bibliográficos
Autores principales: Foglizzo, Martina, Middleton, Adam J., Burgess, Abigail E., Crowther, Jennifer M., Dobson, Renwick C. J., Murphy, James M., Day, Catherine L., Mace, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158172/
https://www.ncbi.nlm.nih.gov/pubmed/30258054
http://dx.doi.org/10.1038/s41467-018-06186-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158172/
https://www.ncbi.nlm.nih.gov/pubmed/30258054
http://dx.doi.org/10.1038/s41467-018-06186-1

Ejemplares similares