Cargando…

A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes

Attachment of ubiquitin to lysine 119 of Histone 2A (H2AK119Ub) is an epigenetic mark characteristic of repressed developmental genes, which is removed by the Polycomb Repressive-Deubiquitinase (PR-DUB) complex. Here we report the crystal structure of the Drosophila PR-DUB, revealing that the deubiq...

Descripción completa

Detalles Bibliográficos
Autores principales:	Foglizzo, Martina, Middleton, Adam J., Burgess, Abigail E., Crowther, Jennifer M., Dobson, Renwick C. J., Murphy, James M., Day, Catherine L., Mace, Peter D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158172/ https://www.ncbi.nlm.nih.gov/pubmed/30258054 http://dx.doi.org/10.1038/s41467-018-06186-1

Ejemplares similares

Molecular Regulation of the Polycomb Repressive-Deubiquitinase
por: Reddington, Cameron J., et al.
Publicado: (2020)

Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes
por: King, Hamish W., et al.
Publicado: (2018)

Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1
por: Thomas, Jonathan F., et al.
Publicado: (2023)

Structural basis of histone H2A lysine 119 deubiquitination by Polycomb Repressive Deubiquitinase BAP1/ASXL1
por: Thomas, Jonathan F., et al.
Publicado: (2023)

Molecular architecture of polycomb repressive complexes
por: Chittock, Emily C., et al.
Publicado: (2017)

Combinatorial Interactions Are Required for the Efficient Recruitment of Pho Repressive Complex (PhoRC) to Polycomb Response Elements
por: Kahn, Tatyana G., et al.
Publicado: (2014)

The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1
por: Middleton, Adam J., et al.
Publicado: (2017)

Huntingtin facilitates polycomb repressive complex 2
por: Seong, Ihn Sik, et al.
Publicado: (2010)

Repressive LTR Nucleosome Positioning by the BAF Complex Is Required for HIV Latency
por: Rafati, Haleh, et al.
Publicado: (2011)

The molecular principles of gene regulation by Polycomb repressive complexes
por: Blackledge, Neil P., et al.
Publicado: (2021)

Insulators Target Active Genes to Transcription Factories and Polycomb-Repressed Genes to Polycomb Bodies
por: Li, Hua-Bing, et al.
Publicado: (2013)

The structure of Polycomb-repressed chromatin in the bithorax complex
por: Bowman, Sarah K, et al.
Publicado: (2013)

Evolutionary adaptation of the Polycomb repressive complex 2
por: Fischer, Sabrina, et al.
Publicado: (2022)

Polycomb Recruiters Inside and Outside of the Repressed Domains
por: Erokhin, Maksim, et al.
Publicado: (2023)

Promiscuous RNA binding by Polycomb Repressive Complex 2
por: Davidovich, Chen, et al.
Publicado: (2013)

The ACF chromatin-remodeling complex is essential for Polycomb repression
por: Wiles, Elizabeth T, et al.
Publicado: (2022)

Nuclear Vav3 is required for polycomb repression complex-1 activity in B-cell lymphoblastic leukemogenesis
por: Nayak, R. C., et al.
Publicado: (2022)

Correction: Repressive LTR Nucleosome Positioning by the BAF Complex Is Required for HIV Latency
por: Rafati, Haleh, et al.
Publicado: (2015)

Molecular architecture of human polycomb repressive complex 2
por: Ciferri, Claudio, et al.
Publicado: (2012)

HDAC inhibitors repress the polycomb protein BMI1
por: Grant, Steven
Publicado: (2010)

Polycomb repressive complex 1 controls uterine decidualization
por: Bian, Fenghua, et al.
Publicado: (2016)

Polycomb Repressive Complex 2 in Eukaryotes—An Evolutionary Perspective
por: Vijayanathan, Mallika, et al.
Publicado: (2022)

De Novo Polycomb Recruitment and Repressive Domain Formation
por: Hernández-Romero, Itzel Alejandra, et al.
Publicado: (2022)

Critical Roles of Polycomb Repressive Complexes in Transcription and Cancer
por: Dong, Guan-Jun, et al.
Publicado: (2022)

The Contribution of the Zebrafish Model to the Understanding of Polycomb Repression in Vertebrates
por: Hanot, Mariette, et al.
Publicado: (2023)

Additional Sex Combs-Like 2 Is Required for Polycomb Repressive Complex 2 Binding at Select Targets
por: Lai, Hsiao-Lei, et al.
Publicado: (2013)

A Polycomb repressive complex is required for RNAi-mediated heterochromatin formation and dynamic distribution of nuclear bodies
por: Xu, Jing, et al.
Publicado: (2021)

Gene silencing in HIV-1 latency by polycomb repressive group
por: Kim, Hyeon Guk, et al.
Publicado: (2011)

Possible roles for polycomb repressive complex 2 in cereal endosperm
por: Tonosaki, Kaoru, et al.
Publicado: (2015)

LATS2 Positively Regulates Polycomb Repressive Complex 2
por: Torigata, Kosuke, et al.
Publicado: (2016)

RNAi-dependent Polycomb repression controls transposable elements in Tetrahymena
por: Zhao, Xiaolu, et al.
Publicado: (2019)

Polycomb repressive complex 1 modifies transcription of active genes
por: Pherson, Michelle, et al.
Publicado: (2017)

Polycomb Repressive Complex(es) and Their Role in Adult Stem Cells
por: Flora, Pooja, et al.
Publicado: (2021)

Transient Polycomb activity represses developmental genes in growing oocytes
por: Jarred, Ellen G., et al.
Publicado: (2022)

Increased Maternal Genome Dosage Bypasses the Requirement of the FIS Polycomb Repressive Complex 2 in Arabidopsis Seed Development
por: Kradolfer, David, et al.
Publicado: (2013)

Proximity-dependent recruitment of Polycomb repressive complexes by the lncRNA Airn
por: Braceros, Aki K., et al.
Publicado: (2023)

Repression of FLOWERING LOCUS C and FLOWERING LOCUS T by the Arabidopsis Polycomb Repressive Complex 2 Components
por: Jiang, Danhua, et al.
Publicado: (2008)

Polycomb Repressive Complex 1 Controls Maintenance of Fungiform Papillae by Repressing Sonic Hedgehog Expression
por: Bar, Carmit, et al.
Publicado: (2019)

BRCA1–BARD1 combines multiple chromatin recognition modules to bridge nascent nucleosomes
por: Burdett, Hayden, et al.
Publicado: (2023)

Synthesis and Characterization of Bidentate Isonitrile Iron Complexes
por: Till, Marion, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_bnh8dkeap8leurgpitk2ndvovv