Cargando…
Structural basis for broad neutralization of ebolaviruses by an antibody targeting the glycoprotein fusion loop
The severity of the 2014–2016 ebolavirus outbreak in West Africa expedited clinical development of therapeutics and vaccines though the countermeasures on hand were largely monospecific and lacked efficacy against other ebolavirus species that previously emerged. Recent studies indicate that ebolavi...
Autores principales: | Janus, Benjamin M., van Dyk, Nydia, Zhao, Xuelian, Howell, Katie A., Soto, Cinque, Aman, M. Javad, Li, Yuxing, Fuerst, Thomas R., Ofek, Gilad |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158212/ https://www.ncbi.nlm.nih.gov/pubmed/30258051 http://dx.doi.org/10.1038/s41467-018-06113-4 |
Ejemplares similares
-
Structural Basis of Broad Ebolavirus Neutralization by a Human Survivor Antibody
por: West, Brandyn R., et al.
Publicado: (2019) -
Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein
por: Gilchuk, Pavlo, et al.
Publicado: (2018) -
Structural Basis for Differential Neutralization of Ebolaviruses
por: Bale, Shridhar, et al.
Publicado: (2012) -
Cooperativity Enables Non-neutralizing Antibodies to Neutralize Ebolavirus
por: Howell, Katie A., et al.
Publicado: (2017) -
Structural Biology Illuminates Molecular Determinants of Broad Ebolavirus Neutralization by Human Antibodies for Pan-Ebolavirus Therapeutic Development
por: Murin, Charles D., et al.
Publicado: (2022)