Identification of small-molecule ion channel modulators in C. elegans channelopathy models

Ion channels are important therapeutic targets, but the discovery of ion channel drugs remains challenging due to a lack of assays that allow high-throughput screening in the physiological context. Here we report C. elegans phenotype-based methods for screening ion channel drugs. Expression of modif...

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Detalles Bibliográficos
Autores principales: Jiang, Qiang, Li, Kai, Lu, Wen-Jing, Li, Shuang, Chen, Xin, Liu, Xi-Juan, Yuan, Jie, Ding, Qiurong, Lan, Feng, Cai, Shi-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158242/
https://www.ncbi.nlm.nih.gov/pubmed/30258187
http://dx.doi.org/10.1038/s41467-018-06514-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158242/
https://www.ncbi.nlm.nih.gov/pubmed/30258187
http://dx.doi.org/10.1038/s41467-018-06514-5

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