The antipsychotic agent trifluoperazine hydrochloride suppresses triple-negative breast cancer tumor growth and brain metastasis by inducing G0/G1 arrest and apoptosis

Women with aggressive triple-negative breast cancer (TNBC) are at high risk of brain metastasis, which has no effective therapeutic option partially due to the poor penetration of drugs across the blood−brain barrier. Trifluoperazine (TFP) is an approved antipsychotic drug with good bioavailability...

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Detalles Bibliográficos
Autores principales: Feng, Zhanzhan, Xia, Yong, Gao, Tiantao, Xu, Fuyan, Lei, Qian, Peng, Cuiting, Yang, Yufei, Xue, Qiang, Hu, Xi, Wang, Qianqian, Wang, Ranran, Ran, Zhiqiang, Zeng, Zhilin, Yang, Nan, Xie, Zixin, Yu, Luoting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158270/
https://www.ncbi.nlm.nih.gov/pubmed/30258182
http://dx.doi.org/10.1038/s41419-018-1046-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158270/
https://www.ncbi.nlm.nih.gov/pubmed/30258182
http://dx.doi.org/10.1038/s41419-018-1046-3

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