Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries

Characterizing the binding selectivity landscape of interacting proteins is crucial both for elucidating the underlying mechanisms of their interaction and for developing selective inhibitors. However, current mapping methods are laborious and cannot provide a sufficiently comprehensive description...

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Detalles Bibliográficos
Autores principales: Naftaly, Si, Cohen, Itay, Shahar, Anat, Hockla, Alexandra, Radisky, Evette S., Papo, Niv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158287/
https://www.ncbi.nlm.nih.gov/pubmed/30258049
http://dx.doi.org/10.1038/s41467-018-06403-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158287/
https://www.ncbi.nlm.nih.gov/pubmed/30258049
http://dx.doi.org/10.1038/s41467-018-06403-x

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