Inhibition of glioblastoma cell proliferation, invasion, and mechanism of action of a novel hydroxamic acid hybrid molecule

Glioblastoma multiforme is one of the most aggressive brain tumors and current therapies with temozolomide or suberoylanilide hydroxamic acid (SAHA, vorinostat) show considerable limitations. SAHA is a histone deacetylase (HDAC) inhibitor that can cause undesirable side effects due to the lack of se...

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Detalles Bibliográficos
Autores principales: Zhang, Issan, Beus, Maja, Stochaj, Ursula, Le, Phuong Uyen, Zorc, Branka, Rajić, Zrinka, Petrecca, Kevin, Maysinger, Dusica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158288/
https://www.ncbi.nlm.nih.gov/pubmed/30302275
http://dx.doi.org/10.1038/s41420-018-0103-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158288/
https://www.ncbi.nlm.nih.gov/pubmed/30302275
http://dx.doi.org/10.1038/s41420-018-0103-0

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