A functional genetic screen reveals sequence preferences within a key tertiary interaction in cobalamin riboswitches required for ligand selectivity

Riboswitches are structured mRNA sequences that regulate gene expression by directly binding intracellular metabolites. Generating the appropriate regulatory response requires the RNA rapidly and stably acquire higher-order structure to form the binding pocket, bind the appropriate effector molecule...

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Detalles Bibliográficos
Autores principales: Polaski, Jacob T, Kletzien, Otto A, Drogalis, Lea K, Batey, Robert T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158498/
https://www.ncbi.nlm.nih.gov/pubmed/29945209
http://dx.doi.org/10.1093/nar/gky539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158498/
https://www.ncbi.nlm.nih.gov/pubmed/29945209
http://dx.doi.org/10.1093/nar/gky539

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