Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2

Despite their central importance in mammalian development, the mechanisms that regulate the DNA methylation machinery and thereby the generation of genomic methylation patterns are still poorly understood. Here, we identify the 5mC-binding protein MeCP2 as a direct and strong interactor of DNA methy...

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Detalles Bibliográficos
Autores principales: Rajavelu, Arumugam, Lungu, Cristiana, Emperle, Max, Dukatz, Michael, Bröhm, Alexander, Broche, Julian, Hanelt, Ines, Parsa, Edris, Schiffers, Sarah, Karnik, Rahul, Meissner, Alexander, Carell, Thomas, Rathert, Philipp, Jurkowska, Renata Z, Jeltsch, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158614/
https://www.ncbi.nlm.nih.gov/pubmed/30102379
http://dx.doi.org/10.1093/nar/gky715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158614/
https://www.ncbi.nlm.nih.gov/pubmed/30102379
http://dx.doi.org/10.1093/nar/gky715

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