The deoxyribose phosphate lyase of DNA polymerase β suppresses a processive DNA synthesis to prevent trinucleotide repeat instability

Trinucleotide repeat (TNR) instability is associated with over 42 neurodegenerative diseases and cancer, for which the molecular mechanisms remain to be elucidated. We have shown that the DNA base excision repair (BER) pathway and its central component, DNA polymerase β (pol β), in particular, its p...

Descripción completa

Detalles Bibliográficos
Autores principales: Lai, Yanhao, Weizmann, Yossi, Liu, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158618/
https://www.ncbi.nlm.nih.gov/pubmed/30085293
http://dx.doi.org/10.1093/nar/gky700

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158618/
https://www.ncbi.nlm.nih.gov/pubmed/30085293
http://dx.doi.org/10.1093/nar/gky700

Ejemplares similares