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Structure-specific endonuclease activity of SNM1A enables processing of a DNA interstrand crosslink
DNA interstrand crosslinks (ICLs) covalently join opposing strands, blocking both replication and transcription, therefore making ICL-inducing compounds highly toxic and ideal anti-cancer agents. While incisions surrounding the ICL are required to remove damaged DNA, it is currently unclear which en...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158701/ https://www.ncbi.nlm.nih.gov/pubmed/30165656 http://dx.doi.org/10.1093/nar/gky759 |