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Structure-specific endonuclease activity of SNM1A enables processing of a DNA interstrand crosslink

DNA interstrand crosslinks (ICLs) covalently join opposing strands, blocking both replication and transcription, therefore making ICL-inducing compounds highly toxic and ideal anti-cancer agents. While incisions surrounding the ICL are required to remove damaged DNA, it is currently unclear which en...

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Detalles Bibliográficos
Autores principales:	Buzon, Beverlee, Grainger, Ryan, Huang, Simon, Rzadki, Cameron, Junop, Murray S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158701/ https://www.ncbi.nlm.nih.gov/pubmed/30165656 http://dx.doi.org/10.1093/nar/gky759

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