DNA base sequence effects on bulky lesion-induced conformational heterogeneity during DNA replication

4-Aminobiphenyl (ABP) and its structure analog 2-aminofluorene (AF) are well-known carcinogens. In the present work, an unusual sequence effect in the 5′-CTTCTG(1)G(2)TCCTCATTC-3′ DNA duplex is reported for ABP- and AF-modified G. Specifically, the ABP modification at G(1) resulted in a mixture of 6...

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Detalles Bibliográficos
Autores principales: Cai, Ang, Wilson, Katie A, Patnaik, Satyakam, Wetmore, Stacey D, Cho, Bongsup P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158707/
https://www.ncbi.nlm.nih.gov/pubmed/29800374
http://dx.doi.org/10.1093/nar/gky409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158707/
https://www.ncbi.nlm.nih.gov/pubmed/29800374
http://dx.doi.org/10.1093/nar/gky409

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