Chemical genetic inhibition of DEAD-box proteins using covalent complementarity

DEAD-box proteins are an essential class of enzymes involved in all stages of RNA metabolism. The study of DEAD-box proteins is challenging in a native setting since they are structurally similar, often essential and display dosage sensitivity. Pharmacological inhibition would be an ideal tool to pr...

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Detalles Bibliográficos
Autores principales: Barkovich, Krister J, Moore, Megan K, Hu, Qi, Shokat, Kevan M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158709/
https://www.ncbi.nlm.nih.gov/pubmed/30102385
http://dx.doi.org/10.1093/nar/gky706

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158709/
https://www.ncbi.nlm.nih.gov/pubmed/30102385
http://dx.doi.org/10.1093/nar/gky706

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