The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells

The circadian protein Nocturnin (NOCT) belongs to the exonuclease, endonuclease and phosphatase superfamily and is most similar to the CCR4-class of deadenylases that degrade the poly-adenosine tails of mRNAs. NOCT-deficient mice are resistant to high-fat diet induced weight gain, and exhibit dysreg...

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Detalles Bibliográficos
Autores principales: Abshire, Elizabeth T, Chasseur, Jennifer, Bohn, Jennifer A, Del Rizzo, Paul A, Freddolino, Peter L, Goldstrohm, Aaron C, Trievel, Raymond C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158716/
https://www.ncbi.nlm.nih.gov/pubmed/29860338
http://dx.doi.org/10.1093/nar/gky412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158716/
https://www.ncbi.nlm.nih.gov/pubmed/29860338
http://dx.doi.org/10.1093/nar/gky412

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