Cargando…

The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells

The circadian protein Nocturnin (NOCT) belongs to the exonuclease, endonuclease and phosphatase superfamily and is most similar to the CCR4-class of deadenylases that degrade the poly-adenosine tails of mRNAs. NOCT-deficient mice are resistant to high-fat diet induced weight gain, and exhibit dysreg...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abshire, Elizabeth T, Chasseur, Jennifer, Bohn, Jennifer A, Del Rizzo, Paul A, Freddolino, Peter L, Goldstrohm, Aaron C, Trievel, Raymond C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158716/ https://www.ncbi.nlm.nih.gov/pubmed/29860338 http://dx.doi.org/10.1093/nar/gky412

Ejemplares similares

The bacterial ribonuclease P holoenzyme requires specific, conserved residues for efficient catalysis and substrate positioning
por: Reiter, Nicholas J., et al.
Publicado: (2012)

Ribonuclease P processes polycistronic tRNA transcripts in Escherichia coli independent of ribonuclease E
por: Mohanty, Bijoy K., et al.
Publicado: (2007)

Inhibition of homologous phosphorolytic ribonucleases by citrate may represent an evolutionarily conserved communicative link between RNA degradation and central metabolism
por: Stone, Carlanne M., et al.
Publicado: (2017)

Characterization of Aquifex aeolicus ribonuclease III and the reactivity epitopes of its pre-ribosomal RNA substrates
por: Shi, Zhongjie, et al.
Publicado: (2011)

Archaeal β-CASP ribonucleases of the aCPSF1 family are orthologs of the eukaryal CPSF-73 factor
por: Phung, Duy Khanh, et al.
Publicado: (2013)

MCPIP1 ribonuclease exhibits broad-spectrum antiviral effects through viral RNA binding and degradation
por: Lin, Ren-Jye, et al.
Publicado: (2013)

Fuse to defuse: a self-limiting ribonuclease-ring nuclease fusion for type III CRISPR defence
por: Samolygo, Aleksei, et al.
Publicado: (2020)

TbMP42 is a structure-sensitive ribonuclease that likely follows a metal ion catalysis mechanism
por: Niemann, Moritz, et al.
Publicado: (2008)

Examining the ribonuclease H primer grip of HIV-1 reverse transcriptase by charge neutralization of RNA/DNA hybrids
por: Dash, Chandravanu, et al.
Publicado: (2008)

Drosophila melanogaster Dis3 N-terminal domains are required for ribonuclease activities, nuclear localization and exosome interactions
por: Mamolen, Megan, et al.
Publicado: (2010)

Sequence-specific cleavage of the RNA strand in DNA–RNA hybrids by the fusion of ribonuclease H with a zinc finger
por: Sulej, Agata A., et al.
Publicado: (2012)

Allosteric regulation of Csx1, a type IIIB-associated CARF domain ribonuclease by RNAs carrying a tetraadenylate tail
por: Han, Wenyuan, et al.
Publicado: (2017)

Regulatory roles of vertebrate Nocturnin: insights and remaining mysteries
por: Hughes, Kelsey L., et al.
Publicado: (2018)

Evolutionarily conserved and non-conserved retrovirus restriction activities of artiodactyl APOBEC3F proteins
por: Jónsson, Stefán R., et al.
Publicado: (2006)

Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase
por: Chen, Jianhong, et al.
Publicado: (2015)

Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes
por: Li, Fuyang, et al.
Publicado: (2007)

Altered target site specificity variants of the I-PpoI His-Cys box homing endonuclease
por: Eklund, Jennifer L., et al.
Publicado: (2007)

Region 3.2 of the σ factor controls the stability of rRNA promoter complexes and potentiates their repression by DksA
por: Pupov, Danil, et al.
Publicado: (2018)

Regulatory circuit based on autogenous activation-repression: roles of C-boxes and spacer sequences in control of the PvuII restriction-modification system
por: Mruk, Iwona, et al.
Publicado: (2007)

Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses
por: Lehmann, Kathleen C., et al.
Publicado: (2015)

VapCs of Mycobacterium tuberculosis cleave RNAs essential for translation
por: Winther, Kristoffer, et al.
Publicado: (2016)

Length heterogeneity at conserved sequence block 2 in human mitochondrial DNA acts as a rheostat for RNA polymerase POLRMT activity
por: Tan, Benedict G., et al.
Publicado: (2016)

Topology of Type II REases revisited; structural classes and the common conserved core
por: Niv, Masha Y., et al.
Publicado: (2007)

Native homing endonucleases can target conserved genes in humans and in animal models
por: Barzel, Adi, et al.
Publicado: (2011)

Constraints on error rate revealed by computational study of G•U tautomerization in translation
por: Kazantsev, Andriy, et al.
Publicado: (2021)

Human TRMT2A methylates tRNA and contributes to translation fidelity
por: Witzenberger, Monika, et al.
Publicado: (2023)

Characterization of the dual role of Plasmodium falciparum DNA methyltransferase in regulating transcription and translation
por: Lucky, Amuza B, et al.
Publicado: (2023)

Coupling of DNA binding and helicase activity is mediated by a conserved loop in the MCM protein
por: Sakakibara, Nozomi, et al.
Publicado: (2008)

An aminoacyl-tRNA synthetase:elongation factor complex for substrate channeling in archaeal translation
por: Hausmann, Corinne D., et al.
Publicado: (2007)

Accuracy of genetic code translation and its orthogonal corruption by aminoglycosides and Mg(2+) ions
por: Zhang, Jingji, et al.
Publicado: (2018)

Evolutionary insights into Trm112-methyltransferase holoenzymes involved in translation between archaea and eukaryotes
por: van Tran, Nhan, et al.
Publicado: (2018)

Myg1 exonuclease couples the nuclear and mitochondrial translational programs through RNA processing
por: Grover, Ritika, et al.
Publicado: (2019)

Activation of RegB endoribonuclease by S1 ribosomal protein requires an 11 nt conserved sequence
por: Durand, Sylvain, et al.
Publicado: (2006)

A conserved loop–wedge motif moderates reaction site search and recognition by FEN1
por: Thompson, Mark J, et al.
Publicado: (2018)

A comparative analysis of two conserved motifs in bacterial poly(A) polymerase and CCA-adding enzyme
por: Just, Andrea, et al.
Publicado: (2008)

Residues of E. coli topoisomerase I conserved for interaction with a specific cytosine base to facilitate DNA cleavage
por: Narula, Gagandeep, et al.
Publicado: (2012)

Meiotic recombination protein Rec12: functional conservation, crossover homeostasis and early crossover/non-crossover decision
por: Kan, Fengling, et al.
Publicado: (2011)

Escherichia coli ItaT is a type II toxin that inhibits translation by acetylating isoleucyl-tRNA(Ile)
por: Wilcox, Brendan, et al.
Publicado: (2018)

The recognition of structured elements by a conserved groove distant from domains associated with catalysis is an essential determinant of RNase E
por: Clarke, Justin E, et al.
Publicado: (2023)

Identification of two conserved aspartic acid residues required for DNA digestion by a novel thermophilic Exonuclease VII in Thermotoga maritima
por: Larrea, Andres A., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_jln5vnin9r8u9ed084j3b93hgj