UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy

Deafferentation of motor neurons as a result of defective sensory-motor connectivity is a critical early event in the pathogenesis of spinal muscular atrophy, but the underlying molecular pathways remain unknown. We show that restoration of ubiquitin-like modifier-activating enzyme 1 (UBA1) was suff...

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Detalles Bibliográficos
Autores principales: Shorrock, Hannah K, van der Hoorn, Dinja, Boyd, Penelope J, Llavero Hurtado, Maica, Lamont, Douglas J, Wirth, Brunhilde, Sleigh, James N, Schiavo, Giampietro, Wishart, Thomas M, Groen, Ewout J N, Gillingwater, Thomas H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158753/
https://www.ncbi.nlm.nih.gov/pubmed/30239612
http://dx.doi.org/10.1093/brain/awy237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158753/
https://www.ncbi.nlm.nih.gov/pubmed/30239612
http://dx.doi.org/10.1093/brain/awy237

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