Cargando…

Control of mRNA decapping by autoinhibition

5′ mediated cytoplasmic RNA decay is a conserved cellular process in eukaryotes. While the functions of the structured core domains in this pathway are well-studied, the role of abundant intrinsically disordered regions (IDRs) is lacking. Here we reconstitute the Dcp1:Dcp2 complex containing a porti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paquette, David R, Tibble, Ryan W, Daifuku, Tristan S, Gross, John D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158755/ https://www.ncbi.nlm.nih.gov/pubmed/29618050 http://dx.doi.org/10.1093/nar/gky233

Ejemplares similares

A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5′–3′ messenger RNA decay
por: Chang, Chung-Te, et al.
Publicado: (2019)

Pseudouridine-mediated translation control of mRNA by methionine aminoacyl tRNA synthetase
por: Levi, Ofri, et al.
Publicado: (2020)

When translation elongation is impaired, the mRNA is uniformly destabilized by the RNA degradosome, while the concentration of mRNA is altered along the molecule
por: Duviau, Marie-Pierre, et al.
Publicado: (2023)

Determinants of the temperature adaptation of mRNA degradation
por: Jaquet, Vincent, et al.
Publicado: (2022)

Human histone pre-mRNA assembles histone or canonical mRNA-processing complexes by overlapping 3′-end sequence elements
por: Ielasi, Francesco S, et al.
Publicado: (2022)

Alu insertion variants alter mRNA splicing
por: Payer, Lindsay M, et al.
Publicado: (2019)

Dimerization of an umbravirus RNA genome activates subgenomic mRNA transcription
por: Chkuaseli, Tamari, et al.
Publicado: (2023)

The mRNA repressor TRIM71 cooperates with Nonsense-Mediated Decay factors to destabilize the mRNA of CDKN1A/p21
por: Torres-Fernández, Lucia A, et al.
Publicado: (2019)

Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal
por: Glasser, Eliezra, et al.
Publicado: (2022)

A combinatorial code for mRNA 3′-UTR-mediated translational control in the mouse oocyte
por: Dai, Xing-Xing, et al.
Publicado: (2019)

SMG-6 mRNA cleavage stalls ribosomes near premature stop codons in vivo
por: Kim, John H, et al.
Publicado: (2022)

Dynamic m(6)A modification regulates local translation of mRNA in axons
por: Yu, Jun, et al.
Publicado: (2018)

ALYREF mainly binds to the 5′ and the 3′ regions of the mRNA in vivo
por: Shi, Min, et al.
Publicado: (2017)

Structure and dynamics of the quaternary hunchback mRNA translation repression complex
por: Macošek, Jakub, et al.
Publicado: (2021)

Transcription feedback dynamics in the wake of cytoplasmic mRNA degradation shutdown
por: Chappleboim, Alon, et al.
Publicado: (2022)

The mTOR regulated RNA-binding protein LARP1 requires PABPC1 for guided mRNA interaction
por: Smith, Ewan M, et al.
Publicado: (2020)

Quasi-essentiality of RNase Y in Bacillus subtilis is caused by its critical role in the control of mRNA homeostasis
por: Benda, Martin, et al.
Publicado: (2021)

The nascent polypeptide-associated complex (NAC) controls translation initiation in cis by recruiting nucleolin to the encoding mRNA
por: Zheng, Alice J L, et al.
Publicado: (2022)

mRNA- and factor-driven dynamic variability controls eIF4F-cap recognition for translation initiation
por: Çetin, Burak, et al.
Publicado: (2022)

The ribosome quality control factor Asc1 determines the fate of HSP70 mRNA on and off the ribosome
por: Alagar Boopathy, Lokha R, et al.
Publicado: (2023)

Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA
por: Powers, Kyle T, et al.
Publicado: (2021)

Contrasting silencing mechanisms of the same target mRNA by two regulatory RNAs in Escherichia coli
por: Lalaouna, David, et al.
Publicado: (2018)

Intra-axonal translation of Khsrp mRNA slows axon regeneration by destabilizing localized mRNAs
por: Patel, Priyanka, et al.
Publicado: (2022)

DDX49 is an RNA helicase that affects translation by regulating mRNA export and the levels of pre-ribosomal RNA
por: Awasthi, Sharad, et al.
Publicado: (2018)

Characterization of zygotic genome activation-dependent maternal mRNA clearance in mouse
por: Sha, Qian-Qian, et al.
Publicado: (2020)

Regulation of AR mRNA translation in response to acute AR pathway inhibition
por: Somasekharan, Syam Prakash, et al.
Publicado: (2021)

Seryl-tRNA synthetase promotes translational readthrough by mRNA binding and involvement of the selenocysteine incorporation machinery
por: Liu, Ze, et al.
Publicado: (2023)

An RNA pseudoknot is essential for standby-mediated translation of the tisB toxin mRNA in Escherichia coli
por: Romilly, Cédric, et al.
Publicado: (2020)

Npl3 functions in mRNP assembly by recruitment of mRNP components to the transcription site and their transfer onto the mRNA
por: Keil, Philipp, et al.
Publicado: (2022)

mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1
por: Jia, Jian-Jun, et al.
Publicado: (2021)

Direct role for the Drosophila GIGYF protein in 4EHP-mediated mRNA repression
por: Ruscica, Vincenzo, et al.
Publicado: (2019)

Alternative splicing of BCL-x is controlled by RBM25 binding to a G-quadruplex in BCL-x pre-mRNA
por: Le Sénéchal, Ronan, et al.
Publicado: (2023)

Functional expansion of a TCA cycle operon mRNA by a 3′ end-derived small RNA
por: Miyakoshi, Masatoshi, et al.
Publicado: (2019)

The conserved 3′ UTR-derived small RNA NarS mediates mRNA crossregulation during nitrate respiration
por: Wang, Chuan, et al.
Publicado: (2020)

METTL3 counteracts premature aging via m(6)A-dependent stabilization of MIS12 mRNA
por: Wu, Zeming, et al.
Publicado: (2020)

Translation initiation of alphavirus mRNA reveals new insights into the topology of the 48S initiation complex
por: Toribio, René, et al.
Publicado: (2018)

In vivo analysis of influenza A mRNA secondary structures identifies critical regulatory motifs
por: Simon, Lisa Marie, et al.
Publicado: (2019)

Structural recognition of the mRNA 3′ UTR by PUF-8 restricts the lifespan of C. elegans
por: Xu, Zheng, et al.
Publicado: (2021)

Discovery of a pre-mRNA structural scaffold as a contributor to the mammalian splicing code
por: Saha, Kaushik, et al.
Publicado: (2021)

Phosphorylation of ribosomal protein S6 differentially affects mRNA translation based on ORF length
por: Bohlen, Jonathan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_87j20jcsmfbrleg1tfq4v9ejum