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Protein interaction and functional data indicate MTHFD2 involvement in RNA processing and translation

BACKGROUND: The folate-coupled metabolic enzyme MTHFD2 is overexpressed in many tumor types and required for cancer cell proliferation, and is therefore of interest as a potential cancer therapeutic target. However, recent evidence suggests that MTHFD2 has a non-enzymatic function which may underlie...

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Detalles Bibliográficos
Autores principales: Koufaris, Costas, Nilsson, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158883/
https://www.ncbi.nlm.nih.gov/pubmed/30275950
http://dx.doi.org/10.1186/s40170-018-0185-4