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Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease
BACKGROUND: Neuronal Ca(2+) dyshomeostasis and hyperactivity play a central role in Alzheimer’s disease pathology and progression. Amyloid-beta together with non-genetic risk-factors of Alzheimer’s disease contributes to increased Ca(2+) influx and aberrant neuronal activity, which accelerates neuro...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158915/ https://www.ncbi.nlm.nih.gov/pubmed/30257685 http://dx.doi.org/10.1186/s13024-018-0283-3 |