Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease

BACKGROUND: Neuronal Ca(2+) dyshomeostasis and hyperactivity play a central role in Alzheimer’s disease pathology and progression. Amyloid-beta together with non-genetic risk-factors of Alzheimer’s disease contributes to increased Ca(2+) influx and aberrant neuronal activity, which accelerates neuro...

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Detalles Bibliográficos
Autores principales: Dumbacher, Michael, Van Dooren, Tom, Princen, Katrien, De Witte, Koen, Farinelli, Mélissa, Lievens, Sam, Tavernier, Jan, Dehaen, Wim, Wera, Stefaan, Winderickx, Joris, Allasia, Sara, Kilonda, Amuri, Spieser, Stéphane, Marchand, Arnaud, Chaltin, Patrick, Hoogenraad, Casper C., Griffioen, Gerard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158915/
https://www.ncbi.nlm.nih.gov/pubmed/30257685
http://dx.doi.org/10.1186/s13024-018-0283-3

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