Development and Validation of an HPLC-MS/MS Method for Rapid Simultaneous Determination of Cefprozil Diastereomers in Human Plasma

BACKGROUND: Both cis- and trans-cefprozil have antimicrobial activity, but their potencies are quite different. It is therefore necessary to develop a sensitive method to simultaneously determine both isomers for pharmacokinetic and bioequivalence studies. METHODS: An LC-MS/MS method, using stable i...

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Detalles Bibliográficos
Autores principales: He, Guodong, Mai, Liping, Wang, Xipei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158942/
https://www.ncbi.nlm.nih.gov/pubmed/30302091
http://dx.doi.org/10.1155/2018/6959761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158942/
https://www.ncbi.nlm.nih.gov/pubmed/30302091
http://dx.doi.org/10.1155/2018/6959761

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