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Development and Validation of an HPLC-MS/MS Method for Rapid Simultaneous Determination of Cefprozil Diastereomers in Human Plasma
BACKGROUND: Both cis- and trans-cefprozil have antimicrobial activity, but their potencies are quite different. It is therefore necessary to develop a sensitive method to simultaneously determine both isomers for pharmacokinetic and bioequivalence studies. METHODS: An LC-MS/MS method, using stable i...
Autores principales: | He, Guodong, Mai, Liping, Wang, Xipei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158942/ https://www.ncbi.nlm.nih.gov/pubmed/30302091 http://dx.doi.org/10.1155/2018/6959761 |
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