Oplopanax horridus: Phytochemistry and Pharmacological Diversity and Structure-Activity Relationship on Anticancer Effects
Oplopanax horridus, well-known as Devil's club, is probably the most important ethnobotanical to most indigenous people living in the Pacific Northwest of North America. Compared with the long history of traditional use and widespread distribution in North America, the study of O. horridus is r...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158975/ https://www.ncbi.nlm.nih.gov/pubmed/30302120 http://dx.doi.org/10.1155/2018/9186926 |
_version_ | 1783358530144698368 |
---|---|
author | Wu, Kai Wang, Chong-Zhi Yuan, Chun-Su Huang, Wei-Hua |
author_facet | Wu, Kai Wang, Chong-Zhi Yuan, Chun-Su Huang, Wei-Hua |
author_sort | Wu, Kai |
collection | PubMed |
description | Oplopanax horridus, well-known as Devil's club, is probably the most important ethnobotanical to most indigenous people living in the Pacific Northwest of North America. Compared with the long history of traditional use and widespread distribution in North America, the study of O. horridus is relatively limited. In the past decade, some exciting advances have been presented on the phytochemistry and pharmacological diversity and structure-activity relationship on anticancer effects of O. horridus. To date, no systematic review has been drafted on the recent advances of O. horridus. In this review, the different phytochemicals in O. horridus are compiled, including purified compounds and volatile components. Animal and in vitro studies are also described and discussed. Especially, the potential structural-activity relationship of polyynes on anticancer effects is highlighted. This review aimed to provide comprehensive and useful information for researching O. horridus and finding potential agents in drug discovery. |
format | Online Article Text |
id | pubmed-6158975 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-61589752018-10-09 Oplopanax horridus: Phytochemistry and Pharmacological Diversity and Structure-Activity Relationship on Anticancer Effects Wu, Kai Wang, Chong-Zhi Yuan, Chun-Su Huang, Wei-Hua Evid Based Complement Alternat Med Review Article Oplopanax horridus, well-known as Devil's club, is probably the most important ethnobotanical to most indigenous people living in the Pacific Northwest of North America. Compared with the long history of traditional use and widespread distribution in North America, the study of O. horridus is relatively limited. In the past decade, some exciting advances have been presented on the phytochemistry and pharmacological diversity and structure-activity relationship on anticancer effects of O. horridus. To date, no systematic review has been drafted on the recent advances of O. horridus. In this review, the different phytochemicals in O. horridus are compiled, including purified compounds and volatile components. Animal and in vitro studies are also described and discussed. Especially, the potential structural-activity relationship of polyynes on anticancer effects is highlighted. This review aimed to provide comprehensive and useful information for researching O. horridus and finding potential agents in drug discovery. Hindawi 2018-09-13 /pmc/articles/PMC6158975/ /pubmed/30302120 http://dx.doi.org/10.1155/2018/9186926 Text en Copyright © 2018 Kai Wu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Wu, Kai Wang, Chong-Zhi Yuan, Chun-Su Huang, Wei-Hua Oplopanax horridus: Phytochemistry and Pharmacological Diversity and Structure-Activity Relationship on Anticancer Effects |
title |
Oplopanax horridus: Phytochemistry and Pharmacological Diversity and Structure-Activity Relationship on Anticancer Effects |
title_full |
Oplopanax horridus: Phytochemistry and Pharmacological Diversity and Structure-Activity Relationship on Anticancer Effects |
title_fullStr |
Oplopanax horridus: Phytochemistry and Pharmacological Diversity and Structure-Activity Relationship on Anticancer Effects |
title_full_unstemmed |
Oplopanax horridus: Phytochemistry and Pharmacological Diversity and Structure-Activity Relationship on Anticancer Effects |
title_short |
Oplopanax horridus: Phytochemistry and Pharmacological Diversity and Structure-Activity Relationship on Anticancer Effects |
title_sort | oplopanax horridus: phytochemistry and pharmacological diversity and structure-activity relationship on anticancer effects |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158975/ https://www.ncbi.nlm.nih.gov/pubmed/30302120 http://dx.doi.org/10.1155/2018/9186926 |
work_keys_str_mv | AT wukai oplopanaxhorridusphytochemistryandpharmacologicaldiversityandstructureactivityrelationshiponanticancereffects AT wangchongzhi oplopanaxhorridusphytochemistryandpharmacologicaldiversityandstructureactivityrelationshiponanticancereffects AT yuanchunsu oplopanaxhorridusphytochemistryandpharmacologicaldiversityandstructureactivityrelationshiponanticancereffects AT huangweihua oplopanaxhorridusphytochemistryandpharmacologicaldiversityandstructureactivityrelationshiponanticancereffects |