Oplopanax horridus: Phytochemistry and Pharmacological Diversity and Structure-Activity Relationship on Anticancer Effects

Oplopanax horridus, well-known as Devil's club, is probably the most important ethnobotanical to most indigenous people living in the Pacific Northwest of North America. Compared with the long history of traditional use and widespread distribution in North America, the study of O. horridus is r...

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Autores principales: Wu, Kai, Wang, Chong-Zhi, Yuan, Chun-Su, Huang, Wei-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158975/
https://www.ncbi.nlm.nih.gov/pubmed/30302120
http://dx.doi.org/10.1155/2018/9186926
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author Wu, Kai
Wang, Chong-Zhi
Yuan, Chun-Su
Huang, Wei-Hua
author_facet Wu, Kai
Wang, Chong-Zhi
Yuan, Chun-Su
Huang, Wei-Hua
author_sort Wu, Kai
collection PubMed
description Oplopanax horridus, well-known as Devil's club, is probably the most important ethnobotanical to most indigenous people living in the Pacific Northwest of North America. Compared with the long history of traditional use and widespread distribution in North America, the study of O. horridus is relatively limited. In the past decade, some exciting advances have been presented on the phytochemistry and pharmacological diversity and structure-activity relationship on anticancer effects of O. horridus. To date, no systematic review has been drafted on the recent advances of O. horridus. In this review, the different phytochemicals in O. horridus are compiled, including purified compounds and volatile components. Animal and in vitro studies are also described and discussed. Especially, the potential structural-activity relationship of polyynes on anticancer effects is highlighted. This review aimed to provide comprehensive and useful information for researching O. horridus and finding potential agents in drug discovery.
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spelling pubmed-61589752018-10-09 Oplopanax horridus: Phytochemistry and Pharmacological Diversity and Structure-Activity Relationship on Anticancer Effects Wu, Kai Wang, Chong-Zhi Yuan, Chun-Su Huang, Wei-Hua Evid Based Complement Alternat Med Review Article Oplopanax horridus, well-known as Devil's club, is probably the most important ethnobotanical to most indigenous people living in the Pacific Northwest of North America. Compared with the long history of traditional use and widespread distribution in North America, the study of O. horridus is relatively limited. In the past decade, some exciting advances have been presented on the phytochemistry and pharmacological diversity and structure-activity relationship on anticancer effects of O. horridus. To date, no systematic review has been drafted on the recent advances of O. horridus. In this review, the different phytochemicals in O. horridus are compiled, including purified compounds and volatile components. Animal and in vitro studies are also described and discussed. Especially, the potential structural-activity relationship of polyynes on anticancer effects is highlighted. This review aimed to provide comprehensive and useful information for researching O. horridus and finding potential agents in drug discovery. Hindawi 2018-09-13 /pmc/articles/PMC6158975/ /pubmed/30302120 http://dx.doi.org/10.1155/2018/9186926 Text en Copyright © 2018 Kai Wu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wu, Kai
Wang, Chong-Zhi
Yuan, Chun-Su
Huang, Wei-Hua
Oplopanax horridus: Phytochemistry and Pharmacological Diversity and Structure-Activity Relationship on Anticancer Effects
title Oplopanax horridus: Phytochemistry and Pharmacological Diversity and Structure-Activity Relationship on Anticancer Effects
title_full Oplopanax horridus: Phytochemistry and Pharmacological Diversity and Structure-Activity Relationship on Anticancer Effects
title_fullStr Oplopanax horridus: Phytochemistry and Pharmacological Diversity and Structure-Activity Relationship on Anticancer Effects
title_full_unstemmed Oplopanax horridus: Phytochemistry and Pharmacological Diversity and Structure-Activity Relationship on Anticancer Effects
title_short Oplopanax horridus: Phytochemistry and Pharmacological Diversity and Structure-Activity Relationship on Anticancer Effects
title_sort oplopanax horridus: phytochemistry and pharmacological diversity and structure-activity relationship on anticancer effects
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158975/
https://www.ncbi.nlm.nih.gov/pubmed/30302120
http://dx.doi.org/10.1155/2018/9186926
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