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Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction
DNA synthesis by DNA polymerases (dPols) is central to duplication and maintenance of the genome in all living organisms. dPols catalyze the formation of a phosphodiester bond between the incoming deoxynucleoside triphosphate and the terminal primer nucleotide with the release of a pyrophosphate (PP...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159520/ https://www.ncbi.nlm.nih.gov/pubmed/29850882 http://dx.doi.org/10.1093/nar/gky402 |