Methylation Profiling RIN3 and MEF2C Identifies Epigenetic Marks Associated with Sporadic Early Onset Alzheimer’s Disease

A number of genetic loci associate with early onset Alzheimer’s disease (EOAD); however, the drivers of this disease remains enigmatic. Genome wide association and in vivo modeling have shown that loss-of-function, e.g., ABCA7, reduced levels of SIRT1 and MEFF2C, or increased levels of PTK2β confer...

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Detalles Bibliográficos
Autores principales: Boden, Kirsty A., Barber, Imelda S., Clement, Naomi, Patel, Tulsi, Guetta-Baranes, Tamar, Brookes, Keeley J., Chappell, Sally, Craigon, Jim, Chapman, Natalie H., Morgan, Kevin, Seymour, Graham B., Bottley, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159661/
https://www.ncbi.nlm.nih.gov/pubmed/30480232
http://dx.doi.org/10.3233/ADR-170015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159661/
https://www.ncbi.nlm.nih.gov/pubmed/30480232
http://dx.doi.org/10.3233/ADR-170015

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