Single-Nucleotide Polymorphism 309T>G in the MDM2 Promoter Determines Functional Outcome After Stroke

BACKGROUND AND PURPOSE—: The E3 ubiquitin ligase MDM2 (murine double minute 2) is the main negative regulator of the p53 protein—a key player in neuronal apoptosis after ischemia. A functional single-nucleotide polymorphism in the human MDM2 gene promoter (rs2279744) regulates MDM2 protein expressio...

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Detalles Bibliográficos
Autores principales: Rodríguez, Cristina, Ramos-Araque, María E., Domínguez-Martínez, Marta, Sobrino, Tomás, Sánchez-Morán, Irene, Agulla, Jesús, Delgado-Esteban, María, Gómez-Sánchez, José C., Bolaños, Juan P., Castillo, José, Almeida, Angeles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Original Contributions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159670/
https://www.ncbi.nlm.nih.gov/pubmed/30355102
http://dx.doi.org/10.1161/STROKEAHA.118.022529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159670/
https://www.ncbi.nlm.nih.gov/pubmed/30355102
http://dx.doi.org/10.1161/STROKEAHA.118.022529

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