Differential Effect of APOE Alleles on Brain Glucose Metabolism in Targeted Replacement Mice: An [(18)F]FDG-μPET Study

BACKGROUND: The Apolipoprotein E (ApoE) alleles ɛ2, ɛ3, and ɛ4 are known to differentially modulate cerebral glucose metabolism and the risk for Alzheimer’s disease (AD) via both amyloid-β (Aβ)-dependent and independent mechanisms. OBJECTIVE: We investigated the influence of ApoE on cerebral glucose...

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Detalles Bibliográficos
Autores principales: Venzi, Marcello, Tóth, Miklós, Häggkvist, Jenny, Bogstedt, Anna, Rachalski, Adeline, Mattsson, Anna, Frumento, Paolo, Farde, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159693/
https://www.ncbi.nlm.nih.gov/pubmed/30480236
http://dx.doi.org/10.3233/ADR-170006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159693/
https://www.ncbi.nlm.nih.gov/pubmed/30480236
http://dx.doi.org/10.3233/ADR-170006

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