MicroRNAs and histone deacetylase inhibition-mediated protection against inflammatory β-cell damage

Inflammatory β-cell failure contributes to type 1 and type 2 diabetes pathogenesis. Pro-inflammatory cytokines cause β-cell dysfunction and apoptosis, and lysine deacetylase inhibitors (KDACi) prevent β-cell failure in vitro and in vivo, in part by reducing NF-κB transcriptional activity. We investi...

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Detalles Bibliográficos
Autores principales: Lindeløv Vestergaard, Anna, Heiner Bang-Berthelsen, Claus, Fløyel, Tina, Lucien Stahl, Jonathan, Christen, Lisa, Taheri Sotudeh, Farzaneh, de Hemmer Horskjær, Peter, Stensgaard Frederiksen, Klaus, Greek Kofod, Frida, Bruun, Christine, Adrian Berchtold, Lukas, Størling, Joachim, Regazzi, Romano, Kaur, Simranjeet, Pociot, Flemming, Mandrup-Poulsen, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160007/
https://www.ncbi.nlm.nih.gov/pubmed/30260972
http://dx.doi.org/10.1371/journal.pone.0203713

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160007/
https://www.ncbi.nlm.nih.gov/pubmed/30260972
http://dx.doi.org/10.1371/journal.pone.0203713

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