Topoisomerases I and III inhibit R-loop formation to prevent unregulated replication in the chromosomal Ter region of Escherichia coli

Type 1A topoisomerases (topos) are the only ubiquitous topos. E. coli has two type 1A topos, topo I (topA) and topo III (topB). Topo I relaxes negative supercoiling in part to inhibit R-loop formation. To grow, topA mutants acquire compensatory mutations, base substitutions in gyrA or gyrB (gyrase)...

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Detalles Bibliográficos
Autores principales: Brochu, Julien, Vlachos-Breton, Émilie, Sutherland, Sarah, Martel, Makisha, Drolet, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160223/
https://www.ncbi.nlm.nih.gov/pubmed/30222737
http://dx.doi.org/10.1371/journal.pgen.1007668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160223/
https://www.ncbi.nlm.nih.gov/pubmed/30222737
http://dx.doi.org/10.1371/journal.pgen.1007668

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