A requirement for slc15a4 in imiquimod-induced systemic inflammation and psoriasiform inflammation in mice

There is competing evidence that plasmacytoid dendritic cells (pDC), the most potent source of IFN-I, may initiate psoriasis. We targeted pDC function using the slc15a4(feeble) loss-of-function mouse whose pDC are unresponsive to TLR agonists. slc15a4(feeble) treated with the topical TLR7-agonist im...

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Detalles Bibliográficos
Autores principales: Griffith, Alexis D., Zaidi, Asifa K., Pietro, Ashley, Hadiono, Matthew, Yang, Jessica S., Davis, Rachel, Popkin, Daniel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160456/
https://www.ncbi.nlm.nih.gov/pubmed/30262916
http://dx.doi.org/10.1038/s41598-018-32668-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160456/
https://www.ncbi.nlm.nih.gov/pubmed/30262916
http://dx.doi.org/10.1038/s41598-018-32668-9

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