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A requirement for slc15a4 in imiquimod-induced systemic inflammation and psoriasiform inflammation in mice
There is competing evidence that plasmacytoid dendritic cells (pDC), the most potent source of IFN-I, may initiate psoriasis. We targeted pDC function using the slc15a4(feeble) loss-of-function mouse whose pDC are unresponsive to TLR agonists. slc15a4(feeble) treated with the topical TLR7-agonist im...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160456/ https://www.ncbi.nlm.nih.gov/pubmed/30262916 http://dx.doi.org/10.1038/s41598-018-32668-9 |