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Dissolution Enhancement in Cocoa Extract, Combining Hydrophilic Polymers through Hot-Melt Extrusion
The aim of this study was to improve the physicochemical properties of cocoa extract (CE) using hot-melt extrusion (HME) for pharmaceutical proposes. A mixture design was applied using three distinct hydrophilic polymeric matrices (Soluplus, Plasdone S630, and Eudragit E). Systems obtained by HME we...
Autores principales: | Pinho, Ludmila A. G., Souza, Saulo G., Marreto, Ricardo N., Sa-Barreto, Livia L., Gratieri, Tais, Gelfuso, Guilherme M., Cunha-Filho, Marcilio |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160995/ https://www.ncbi.nlm.nih.gov/pubmed/30134594 http://dx.doi.org/10.3390/pharmaceutics10030135 |
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