Potential Inherent Stimulation of the Innate Immune System by Nucleic Acid Aptamers and Possible Corrective Approaches

It is well known that unmethylated 2′-deoxycytidine-phosphate-2′-guanine (CpG) sequences alone or in longer DNA and RNA oligonucleotides can act like pathogen-associated molecular patterns (PAMPs) and trigger the innate immune response leading to deleterious cytokine production via Toll-like recepto...

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Detalles Bibliográficos
Autor principal: Bruno, John G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161019/
https://www.ncbi.nlm.nih.gov/pubmed/29937498
http://dx.doi.org/10.3390/ph11030062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161019/
https://www.ncbi.nlm.nih.gov/pubmed/29937498
http://dx.doi.org/10.3390/ph11030062

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