Simultaneous Determination of Chlorogenic Acid Isomers and Metabolites in Rat Plasma Using LC-MS/MS and Its Application to A Pharmacokinetic Study Following Oral Administration of Stauntonia Hexaphylla Leaf Extract (YRA-1909) to Rats

Stauntonia hexaphylla leaf extract (YRA-1909), which is widely used for the antirheumatic properties, has been under phase 2 clinical trials in patients with rheumatoid arthritis since April 2017. Liquid chromatography-tandem mass spectrometric method while using liquid–liquid extraction with ethyl...

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Detalles Bibliográficos
Autores principales: Choi, Won-Gu, Kim, Ju-Hyun, Kim, Dong Kyun, Lee, Yongnam, Yoo, Ji Seok, Shin, Dae Hee, Lee, Hye Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161084/
https://www.ncbi.nlm.nih.gov/pubmed/30200538
http://dx.doi.org/10.3390/pharmaceutics10030143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161084/
https://www.ncbi.nlm.nih.gov/pubmed/30200538
http://dx.doi.org/10.3390/pharmaceutics10030143

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